matol botanical biomune osf plus increase natural killer cell (NK)
THE USE OF DIALYZABLE BOVINE COLOSTRUM EXTRACT IN CONJUCTION WITH A HOLISTIC TREATMENT MODEL FOR NATURAL KILLER CELL STIMULATION IN CHRONIC ILLNESS.

A Report By: Jesse A. Stoff MD, MFHOM, FACLM


CONTENTS

Jesse A. Stoff, MD, MFHOM, FACLM

Dear Friends,

According to the American Cancer Society, by the end of this year cancer will have overtaken heart disease as the number one cause of death amongst adults in this country. In fact they say that one in three of us will get some form of cancer in our lifetime! There are many reasons for this, our environment is full of toxic pollutants that are known to initiate and promote cancer. There are oncogenic viruses that we are commonly exposed to (i.e. EBV, CMV, etc.) and with the thinning of our ozone shield we're subjected to more of the damaging effects of solar radiation. On the other side of the coin our defenses aren't what they once were either. Most of the population is suffering from the combined effects of nutritional deficiencies and stress, but I'm sure that this isn't news to you. With these kinds of challenges our usual recommendations of life-style changes and nutritional supplementation may not be strong enough or soon enough to reduce our risk of severe and chronic disease.

Fortunately, after years of clinical research, there is now available a nutraceutical which passively transfers critical defense information directly to your immune system,thus increasing its surveillance function by increasing your NK cell activity. The nutraceutical is called Biomune OSF Plus and it contains Transfer Factor that was dialyzed from the colostrum of specially immunologically stimulated cows. This extract is then combined with Astragalus, which also has a long and well-documented history of positive immuno-modulation. Brought together, as a result of a patented proprietary process, in a form designed to ensure bioavailability and safety, even in someone who is lactose intolerant or allergic to milk, is a keystone of therapy for my patients and as a measure of prevention for my family and myself.

The best colostrum is produced from organically raised cows and is free of pesticides, herbicides, anabolic steroid hormones, antibiotics and other toxins. From my research and experience, Biomune OSF Plus formula contains extract of colostrum and whey that meets the above criteria and has proven itself to be far superior to regular colostrum. Be prudent, be careful and recommend what's best for your family, your friends, and yourself,

Take care and be well.

Sincerely yours,

Jesse A. Stoff, MD, MFHOM, FACLM

Stanley R. Olsztyn, M.D. (H.), P.C.

Dear friends,

I received my medical degree in 1959. The remarkable advancements in medicine over the past forty years could not then be imagined. Medical technology has an impressive history, but it is sobering to realize that many of the diseases we thought would be eliminated by the turn of the century are now more prevalent than ever.

Degenerative diseases, cancer, heart disease and infections continue to rise while our traditional medical system is at its peak in performance. Infectious disease, once thought totally controllable, is now the third leading cause of death and the leading cause of illness.

In 1979, the realization that synthetic drugs do not always work became painfully evident in my own family. My wife had contracted a staphylococcal sinus infection that only worsened over time as she took course after course of antibiotics. My infant son also had recurring ear and throat infections that responded less and less to ever more potent antibiotics.

With all the modern miracles of medicine, how is it that so many people succumb to so many common, uncontrolled infections? I was shaken when I realized that antibiotics and other synthetic drugs were in themselves often stopping the body from natural recovery. I believe that healing comes from the ability of the body to use its inherent power to function normally. The human immune system has the ability to fight degenerative disease, cancer, heart disease and infectious disease. When the immune system takes-up the fight and wins, we emerge stronger and more prepared to meet future challenges.

I was drawn to a quest that continues even now. I began a search for natural alternatives to antibiotics and other drugs that would help the body function in the way it was designed to function. I consulted my old research notes from medical school, called former professors and contacted immunologists and bacteriologists. I began developing means and techniques for supporting the body's powerful, innate defense systems rather than replacing them with synthetic substitutes. Those early formulas of twenty years ago were the forefather of today's Quantum Research products.

I have seen thousands of patients in my practice who came to me with the same feeling of desperation and hopelessness that I experienced. Using my natural immune system formulations, those patients have been able to regain control of their health that would have been the former challenges of a distant memory.

I truly believe that the future of our society is dependent upon a aligning with the natural forces that give our bodies life and vitality. Today we see an unprecedented interest and utilization of alternative approaches to traditional medicine. From my years of experience in using alternative approaches, I know that Biomune OSF Plus can play a critical role in leading the world to a state of health and wellness.

Sincerely,

Dr. Stanley Olsztyn

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Nature and Purpose of Clinical Studies

Clinical studies such as Dr. Jesse Stoff’s study of the ingredients included in Matol Biomune OSF Plus™ , document the changes experienced by participants who have a specific goal relative to their well-being. These studies appear, in contrast to academic studies, often referred to as "double blind" that are applied to drugs with the intent of establishing the nature of a substance and its effects on the subject.

The questions "what if ?" and "how do we?" are found in studies where the "outcome" is not the main goal. In clinical studies "outcome" is everything. The study itself is a documentation of the "outcome". The only pre-qualifying condition for Dr. Stoff’s studies is the presence of illness.

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A Comparison of Quantum Research, Inc.’s Special Bovine Colostrum/Whey Extract to Other Colostrum and Whey Products

When Dr. Stoff was asked the difference between the Quantum Research extract of bovine colostrum/whey and other colostrum and whey products, his answer was, "That’s easy. One works and one doesn’t."

If you ask how he made that evaluation, he reminds the questioner that he has, for nearly four years, conducted extensive clinical research on the Quantum extract formulations and other colostrum products. He knows from actual clinical experience that regular colostrum may have some value, but has a minimal effect upon any significant immune response.

Dr. Olsztyn and Dr. Stoff believe that the Quantum colostrum/whey extracts are elite and in a class of their own. To be compared to other colostrum and whey products is inevitable, but much like comparing milk to gold such comparisons are meaningless. There is simply nothing tangible to compare.

Reviewing literature of companies that market colostrum or whey products one would get the impression that their commodity is absolutely the most fantastic immune support substance that ever existed. In fact, they probably say that somewhere in self-aggrandizing literature.

The Quantum Research formulations are not in competition with any colostrum or whey products as there is very little comparison, other than the Quantum extract has its origin in cows, as does most regular colostrum.

There is nothing wrong with the commodity colostrum or whey. Both are a good source of protein and as Dr. Stoff said, "they are better than nothing". What are the distinct and important differences between the Quantum Research colostrum/whey extract formula and other formulas?

Quantum Research’s formulation of a special extract of colostrum/whey and immune synergists that includes herbs, and other natural substances. Other colostrum or whey products are simply a commodity like milk or wheat.

Quantum Research formualtions have been clinically tested for their effectiveness by medical doctors before being released to the general public. These clinical studies are also made available to the public.

Quantum Research products include a special extract of colostrum/whey that is produced by a patented pre-calving process of immunological stimulation from an exclusive herd of clean (antibiotic, hormone, pesticide free) and privately managed herd of cattle. A proprietary post-calving process of select collection, ultra-filtration and low heat drying produces a collection of very small molecules that contain transfer factor and other immunological factors. Less than 1% of the original colostrum/whey is retained and only specific molecules are harvested. The same material marketed by other companies as colostrum or whey is discarded and thrown away through this precise process.

Quantum Research formulations have been shown in clinical studies to dramatically and consistently increase natural killer (NK) cell activity. Research indicates that increasing NK cell activity is a tremendous benefit for the restoration and maintenance of health. No other colostrum and whey products can make the NK cell function claim based on clinical studies.


The Importance of Natural Killer Cells In Health and Disease

The clinical study by Dr. Stoff focused on the ability of the ingredients in Biomune OSF Plus™ to increase NK cell function. Any statement that natural killer (NK) cells play an "important role" in human health is as casual as saying that the brain is important for bodily function. If our brain is not present and active, we cannot continue "living". If our immune system is not armed and working well, we will also not continue "living" for very long. NK cell activity is to the immune system what brain activity is to body.

The immune system is comprised of millions of cells, numerous chemicals, glands and organs which all work together via a complex communication system. Immune science uses terms like "antibodies", "antigens", "B cells", "T cells", "macrophages", "cytokines", and in the past few years, "natural killer cells". Natural killer cells have become the focus of much research due to the expanding knowledge of their value in keeping us healthy.

NK cell activity and NK cell count are not the same. NK cells may be present in sufficient numbers, but unless they are activated they are ineffective in doing their job. Decreased NK cell activity is linked to the development and progression of many diseases. According to the Center for Disease Control, low NK cell activity is present in all illness. NK cell function appears to be a biologic marker for disease and is an important indicator for declining or improving health.

The following assertion can be made; if one is suffering from an illness, be it chronic, recurring or acute, the NK cell activity would be below normal. The restoration of NK cell activity to a high normal would be desirable, if not necessary, for recovery. With this in mind, a strategy to accomplish increasing NK cell activity should accompany both the maintenance of good health and the recovery from illness.

ABBREVIATIONS: NK; Natural Killer Cell

Low NK cell activity begins with stress of some type. When the body is unable to adequately adapt to the environment, there is a resulting compromise of body function. Stress comes through loss of sleep, overwork, emotional encounters, lack of exercise, poor nutrition, exposure to toxins, exposure to germs etc.

Acute low NK cell activity resulting from temporary stress can be eliminated with the elimination of the stress factor. For example, if we are over-tired and under-nourished, we can simply rest and eat properly for a few days and recover. However, when we become continually immune compromised we start developing recurring problems which may lead to serious or chronic conditions.

Specific intervention can be necessary to rebuild the immune system in the face of serious or chronic conditions if recovery is to occur. At a certain point, rest and general nutrition are just not enough. This is when most people turn to pharmaceutical products for recovery and symptomatic relief. Unfortunately, this has not been a viable approach, as drugs do not address the deficiencies that are necessary for real and lasting recovery. Drugs do not build up the immune system and often produce a weakening in the long run. The lack of results and the many side effects of drugs have caused millions to turn to alternative approaches for their health recovery.

There are numerous nutritional substances that support the immune system when taken in sufficient quantities and combinations. Vitamin A, vitamin C and vitamin E, zinc, calcium, goldenseal and echinacea, are just a few of the vitamins minerals and herbs that support the immune system. Vitamin C and vitamin E will increase NK cell activity slightly, but not dramatically nor consistently. In fact, the search for a safe and effective strategy to enhance NK cell activity and accordingly, provide effective immune system support has been in progress for several years.

Dr. Stanley R. Olsztyn, a medical doctor specializing in alternative medicine, has been developing such products since the 1970’s. He has been working with and developing special colostrum/whey extracts in combination with herbs, vitamins and other nutritionals. Dr. Olsztyn discovered that colostrum/whey extracts with synergistic nutritional components did, in fact, increase NK cell activity both dramatically and consistently. This explained why the thousands of patients to whom he had given his formulas responded so well and so quickly. In 1993, after 15 years of clinical research and development, he introduced his results to the general public.

Concurrently, Dr. Jesse A. Stoff, a prominent viro-immunologist and researcher, was exploring ways to expand his protocol for immune system support. He conducted extensive laboratory evaluation on his patients in his Tucson clinic and was searching for a "transfer factor" substance that he reasoned would dramatically enhance the immune system. Dr. Stoff became aware of Dr. Olsztyn’s formulas and began evaluating them in his practice. As Dr. Stoff deals primarily with severe and chronic cases, it was a perfect setting to evaluate the Olsztyn products under the most rigid clinical conditions.

Dr. Stoff published the results of his findings using Dr. Olsztyn’s special extract of colostrum and whey in combination with other nutritional factors. The study is most impressive, showing patient response following dramatic increases in their NK cell activity. Recovery and remission from many of the most serious of health problems of this time were documented.

Due to the success of the clinical studies, Dr. Stoff has joined Dr. Olsztyn for continuing research and the development of new products using the special colostrum/whey extract and an array of natural substances. Matol Biomune OSF Plus™ is the first of these new products.


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CLINICAL STUDY

THE USE OF DIALYZABLE BOVINE COLOSTRUM
EXTRACT IN CONJUNCTION WITH A HOLISTIC
TREATMENT MODEL FOR NATURAL KILLER CELL
STIMULATION IN CHRONIC ILLNESS

The following study discusses, summarizes and demonstrates that properly bovine colostrum and whey extracts used in combination with the herb Astragalus will help produce significant increases in Natural killer (NK) cell activity. NK cells are very important in human health and disease. Defective or absent NK cell activity is associated with a spectrum of human diseases. Matol Biomune OSF Plus tm, which combines the herb Astragalus with such an extract from Quantum Research, Inc. is shown to be a critical dietary supplement.

THE USE OF DIALYZABLE BOVINE COLOSTRUM EXTRACT IN CONJUNCTION WITH A HOLISTIC TREATMENT MODEL FOR NATURAL KILLER CELL STIMULATION IN CHRONIC ILLNESS
By: Jesse A. Stoff, MD, MFHOM, FACLM

Abstract:

A longitudinal evaluation of the natural killer cell (NK activity) of peripheral blood lymphocytes was performed in 107 patients with documented and advanced chronic illness and followed for an average period of 13.2 months. At the time of primary evaluation and treatment, the absolute value of natural killer cell activity was significantly lower than the normal range. Hence, the association of chronic illness with the syndrome of low natural killer cell activity.

During the follow-up period, a variety of nutritional agents were given to support natural killer cell function and then dialyzable bovine colostrum extract was added to the protocol. In the ensuing months, the curve of NK cell reactivation into normal ranges and above was monitored as immune system competence was restored.

The use of natural immunomodulators including the use of dialyzable bovine colostrum extract can be concluded as a viable therapeuticum in NK cell reactivation in the face of chronic illness.


Patient outcome discussion

Patient No.
Patient Age
Condition
Month Treated
Initial NK Level
Last NK Level
Comments on Outcome
144 48 CFS, Psoriasis 20 21 780 Back to work, skin improving, high energy
145 50 Colon Polyps 26 1 174 Cured
149 48 Adenocarcinoma 22 1 1030 Remission
150 77 Prostate Cancer 21 7 657 Remission
151 49 Hep C 27 3 390 Remission
152 36 CFS 22 12 380 Feeling well and back to work
153 39 CFS, EBV, Staph 27 8 365 Healthy
154 62 Prostate Cancer 22 3 90 Remission
155 66 Carcinoma 10 4 830 Remission
156 57 Carcinoma 11 9 415 Remission
157 42 Ovarian Cancer 15 23 148 Remission
158 78 Prostate Cancer 3 3 419 Remission
159 50 AIDS 36 1 330 Opportunistic infections ceased
160 61 CFS 25 0 204 Feeling good, near recovery
161 62 Colon Cancer 17 45 466 Stabilized
162 43 Severe Allergies 30 22 315 Resolved
163 56 CFS 23 20 225 Resolved
164 44 CFS & others 24 1 273 Resolved
165 56 CFS 16 26 399 Resolved
166 48 CFS 14 4 172 Resolved
167 41 Bladder Cancer 13 2 148 Resolved
168 76 Prostate Cancer 19 3 92 Remission
169 50 HSV-II 18 6 282 Remission
170 47 CFS, Colon Polyps 20 3 189 Much improved
171 49 CFS 23 1 266 Steadily improving
172 46 Ductal Carcinoma 13 11 179 Remission
173 60 CMV 38 4 297 Cured
174 72 Lymphocytic Leukemia 24 1 89 Stabilized & improved
175 36 CFIDS, HHV-6 59 18 315 Resolved
176 37 Autoimmune Dysfunction 29 1 623 Normal
177 41 Myelodysplasia 9 8 349 Normalized
178 82 Lymphoma (Non Hodgkin) 16 26 634 Stable & progressing
179 58 Lymphocytic Leukemia 39 0 730 Stable & dormant
180 38 Chronic Infection 31 4 368 Normalized
181 36 Colitis, Allergy 36 38 550 Normalized
182 55 B-cell Leukemia 14 5 210 Stable & improving
183 66 Colitis 16 17 125 Much improved
184 65 Prostate Cancer 13 21 367 Stable, good prognosis
185 33 EBV 29 1 295 Full remission
186 41 Thyroditis 20 2 230 Much improved & improving
187 53 CFS 17 16 345 Improving rapidly
188 53 Myelodysplasia 10 5 249 Improving rapidly
189 64 Prostate Cancer 19 14 845 Asymptomatic
190 65 CFIDS, Allergies 23 14 398 Back to work
191 30 Basal Cell Carcinoma 29 51 140 Resolved & remission
192 53 Breast Cancer 22 105 845 Disease free
193 76 Lung Cancer 9 25 88 Stabilized & resolving
194 55 Colon Cancer 12 40 72 Obstruction resolved & asymptomatic
195 59 CFS 5 11 21 Returned to active life, feeling good
196 58 Breast Cancer 8 11 31 Recovering well
198 65 Prostate Cancer 1 2 38 Full remission
199 56 CFS 11 20 127 Energetic & returned to active life
200 62 Colon Cancer 1 45 219 Resolved
201 48 CFS 6 12 101 Recovered & "feels like a new woman"
202 47 Crevical Cancer 4 1 46 Cancer, Herpes & Genital Warts in remission
203 49 Colon Cancer 8 3 49 Remission
204 51 CFS 19 21 780 Returned to active life
205 36 CFS, Lupus 16 7 28 Remission, back to graduate school
206 40 CFS 13 42 185 Recovered
207 48 Ovarian Cancer 12 79 399 Resolved
208 40 CFS 13 17 56 Returned to active life
209 43 Bladder Cancer 15 2 164 Remission
210 67 Prostate Cancer 2 5 103 Remission
211 66 Prostate Cancer 11 14 608 Remission, back to active life
212 50 Parotid Cancer 5 29 142 Remission, back to active life
213 79 Prostate Cancer 20 7 499 Remission
214 54 Breast Cancer 9 47 436 Remission
215 64 CFS 3 0 69 "Spunky again"
216 56 CFS 13 2 41 Full recovery
217 49 Lupus 9 8 38 Remission
218 63 Leukemia 5 117 376 Improving significantly
219 47 Breast Cancer 5 33 689 Avoided surgery, back to normal life
220 70 COPD, CFS 15 1 73 CFS resolved, back to spry grandma
221 53 Breast Cancer, Thyroiditis 10 132 255 Thyroid corrected, cancer remission
222 50 EBV 8 15 28 Doing well, feels alive again
223 44 Ovarian Cancer 3 23 70 Remission
224 39 EBV, Lupus 7 19 66 EBV remission, Lupus has disappeared
225 52 Prostate Cancer 2 5 39 Full remission
226 84 Lymphoma 4 26 69 Full recovery
227 49 Appendix Adenocarcinoma 10 18 56 Full remission
228 50 CFS 3 4 44 Feeling great again
229 77 Cancer 8 82 348 Remission
230 55 CFS 5 18 50 Resolved, returned to career
231 21 EBV, Severe Herpes Stomatitis 14 5 32 Resolved
232 49 Leukemia 0 2 11 Remission
233 57 CFS 8 13 40 Really well, full remission
234 52 CFS 5 2 22 Improving steadily
235 66 Renal Carcinoma 7 3 11 Remission
236 55 Lupus 13 1 15 Recovering well, slowly resolving
237 78 Prostate Cancer 6 3 19 Heavy chemo slowed healing, now in remission
238 40 CFS 15 100 169 Full recovery
239 48 Breast Cancer 4 3 38 Remission
240 31 CFS 1 12 86 Full remission
241 65 Prostate Cancer 1 18 287 Full remission
242 17 Acute Mono 2 0 79 Full recovery very fast
243 46 Ovarian Cancer 1 15 118 Full remission
244 38 Breast Cancer 2 3 218 No sign of disease
245 53 Lung Cancer 2 9 198 Improving significantly
246 68 Colon Cancer 2 36 246 Fully recovered
247 47 Cervical Cancer 2 20 182 Remission
248 31 CFS 2 7 68 Remission in 4 months
249 29 CFS 2 14 92 After 8 years illness, 4 months 90% of old self
250 62 Lymphoma 1 27 68 Tumor decreasing
251 73 Myeloma 2 4 148 Fully recovered
252 26 CFS 2 30 87 Full remission
253 43 Breast Cancer 1 17 289 Improving very nicely
254 58 Myelofibrosis 2 1 79 Making great progress

Clinical Study Summary and Discussion

The participants:

Charts of 107 patients who presented with chronic illness which were known to include low NK cell function were studied to determine their NK cell function response after being treated with a complimentary medical regimen of therapy. This regimen included the use of dialyzable bovine colostrum/whey extracts as well as other elements of the Holistic Medical Paradigm.

The patients all self-selected this medical approach and most came with specific expectations, having read (1) Chronic Fatigue Syndrome: The Hidden Epidemic or, (2) The Definitive Guide to Cancer Therapy.

An overview of the immune system:

The marvelous array of deftly interacting cells that defend our body against invaders, arise from a few precursor cells that first appear at about 9 weeks after conception. From that point on, the cells of the immune system go through a continuously repeated cycle of growth and development and become fully competent at around 6 months of age after our birth.

The parent cells of our immune system are referred to as stem cells. These are the cells upon which the immune system depends to both reproduce itself and gives rise to the many specialized lineage's that spring from it; the B cells, macrophages, natural killer (NK) cells, helper T cells, etc.

The cells of the immune system are not isolated in a single body space or arranged in the form of a single organ. Instead, the majority of them exist as potentially mobile entities unattached to other cells. This characteristic is crucial to their function. Every minute of every day, war is waged within our body. The combatants are too small to see. Some, like the infamous HIV virus, are so small that 230 million would fit on the period at the end of this sentence. Yet, they employ tactics that can vanquish the much larger cells upon which our immune system is based. Usually, we never even notice the battles within us.

We have evolved legions of defenders, specialized cells that silently destroy the unseen enemy. Sometimes these warriors mistake harmless invaders such as pollen for deadly foes and trigger an allergic response. Occasionally, some of our own cells begin the mutinous uncontrolled proliferation characteristic of cancer and manage to evade the surveillance of our body's defensive forces. For every successful penetration of our defenses, millions of attempts are repelled. We sleep securely at night trusting the invisible vigilantes of our immune system.

The science and practice of immunology traces back to 1721 to Lady Mary Wortley Montagu. She introduced England to a Turkish process of inoculation with unmodified smallpox virus in an attempt to stem the ravages of the normal course of the disease. Her techniques were quite crude and as many as her patients died as survived but those that survived were immune to the disease forever more.

Over the decades and centuries, scores of doctors and researchers honed the art of immunology into a more and more refined science. Many of the wonderful blood tests that we have today and information that we now know about immunology was unknown to us a scant 20 years ago. Information on the science of immunology doubles at the rate of approximately every 5 to 6 years. So, we must remember that the wonderful ways that we have today to support and direct the immune system to help protect us and fight off illnesses is a mere foreshadow of things to come in the (near) future

Our immune system is a miracle of evolution. There is interesting research to suggest that elements of our immune system were, at one time, actually independent organisms. They were incorporated into our body, millions and millions of years ago, as a type of symbiotic mutually beneficial relationship. Our immune system is not controlled by any central organ such as the relationship of our brain to our nervous system. Rather, it has developed and functions as a kind of biological democracy where the individual members achieve their ends through an information network of biochemical substances called, "cytokines".

Many different variables in our environment and lifestyle can effect the efficiency of its function. Our immune system accounts for approximately 1% of our body's 100 trillion cells. These defender cells originally arise in our bone marrow and mature in other parts of our body, the thymus, spleen and lymph glands. The different lineage's which develop all share one common objective; to identify and destroy all substances, living or inert, that are recognized as foreign to our body. This includes cancer cells that challenge our immune system everyday for each and every one of us.

NK Cells:

NK cells were discovered in the 1970's and constitute up to 15% of the total lymphocyte population in normal healthy subjects. They are capable of killing a broad range of tumor and virus infected cells. Depressed NK cell activity and depressed NK cell populations are associated with the development and rapid progression of cancer, hepatitis, AIDS, Chronic Fatigue Syndrome, various immunodeficiency syndromes, and certain autoimmune diseases. In my practice I almost exclusively work with people with severe and chronic diseases, that are known to present abnormally low levels of NK cell function.

NK cells now appear to present the first line of defense against metastatic spread of tumors. In numerous studies, low NK cell populations were correlated with greater and more rapid spread of tumors with shorter host longevity and with greater morbidity.

The immune response:

There are four critical phases to the immunological response and lifestyle issues and some dietary supplements can influence them.

During phase one, the offending invader is identified and recognized as being foreign to our body and then quickly consumed by hungry roving macrophages. You can think of macrophages as little PAC men that are found in all of the tissues in our body and circulating around in our blood stream looking for their next free lunch. They seize upon this foreign agent, engulf it, eat it and release a series of cytokines that then trigger the 2nd phase of the immunological reaction.

In phase two, these biochemical substances then activate the helper T cells that have the job of coordinating the counterattack on a body-wide scale. The T cells then begin to multiply and release other cytokines that further stimulate more T cells, B cells, and natural killer cells. As the number of B cells increase, the helper T cells signal them to begin producing antibodies, thus, bringing us to the 3rd stage of the immunological response.

In the third stage, the antibodies are circulating around in our blood stream and are attaching to the foreign virus or bacteria causing them to be more quickly engulfed by macrophages or killed by natural killer cells.

The fourth stage of the immunological response begins when the circulating antibodies no longer have a target and the suppresser T cells call a truce to the immunological reaction bringing about a new balance, or homeostasis, in our system. Special cells of the immune system remember what had transpired so that if again attacked by the same organism, our body could respond much faster. These cells also release special little molecules called, "transfer factor" to help keep the pump primed, so to speak.

Thus, what may have been a 10-day bout from our first exposure to that particular virus, in the future may be a cold that lasts no more than 24-72 hours.

Immune-modulation:

Immune-modulation is a new and key step in supporting immune function. This can include a number of different substances, depending upon the situation, including: transfer factor (obtained in specially prepared colostrum/whey extracts), Astragalus, Arabinogalactan, Viscum extracts, vitamin C, iodine, lactoferrin, certain amino acids, neurotransmitter hormones and the prohormone DHEA.

Transfer Factor:

In the study group, generic NK cell response was monitored using transfer factor, obtained in specially prepared colostrum/whey extracts, along with the herb Astragalus that is known to accelerate and support immunological reactions. The transfer factor component was produced from cows that have been immunologically stimulated using a patented process. This process does not hurt the cow. In fact, it stimulates the cow’s immune system for its own protection.

When a cow gives birth to a calf, the first flow of milk is called the colostrum. The colostrum is collected and the transfer factor molecules are extracted. At appropriate opportunities, collection can also occur from the milk following colostrum. This is generally referred to as whey. Since none of the milk proteins remain, these products are safe even for people with a dairy allergy. The purified transfer factor can then be given to people to passively stimulate their NK cells function to alert-activity status, thus protecting them to a significant degree from illness as well as helping them recover from illness.

Lifestyle:

Lifestyle issues that will affect the functioning of our immune system include exposure to toxins (heavy metals, petrochemicals, radiation, etc.) and dietary and nutritional deficiencies that can rob the immune system of the biochemical foundation that it relies upon in order to function normally. Another major lifestyle issue relative to immune function is stress.

Dietary Supplements used by the Study Group:

The use of other nutritional support factors in conjunction with the dialyzable colostrum/whey extract and astragalus was important for patient recovery. However, I want to point out three significant factors in relation to that fact:

Most of the patients were advanced in their conditions and had tried other approaches for their health recovery before I saw them in my clinic.

The dialyzable colostrum/whey extract was critical to their recovery. Without that component, providing the transfer factors discussed herein, many of the patients simply would not have recovered.

I have utilized a wide array of well-known and privately prepared colostrum products with disappointing results. These products were not helpful to my patients as they failed to significantly increase NK cell function or consistently provide any other significant immunological benefits that could be measured.

I also observed that people who were not severely compromised responded well to daily supplementation of the colostrum/whey extract and astragalus without additional nutritional supplementation. Even though adequate nutritional support is important it was noted that the extract of dialyzable colostrum/whey and astragalus is very powerful and valuable in combination without additional supplementation.

The importance of prevention:

With any health problem, it is much more prudent and efficient to prevent disease by maintaining a high level of immune function. Research has shown that low NK cell activity is present nearly all illness. A daily dietary regimen that includes dialyzable bovine colostrum/whey extract has been shown to significantly help maintain high NK cell activity and thereby dramatically increase the ability of the immune system to maintain a healthy condition.

Conclusions:

This Study Group demonstrates that stimulation of NK activity paralleled restored resistance to illness and recovery from illness. NK cell activity is correlated with disease status in those patients with hematologic malignancy such as leukemia and lymphomas as well. In some studies, on patients with leukemia, a sudden and maintained decrease in NK cell activity was reported nearly always to proceed relapse, even if the patient had been in complete remission for some time. This also correlated with a general drop in the percentage of lymphocytes as measured in a standard blood test. NK cell function is a well-regulated activity subject to both inhibitory and excitatory control.


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12. Lange S: Immune mechanisms of cardiac disease. New England Journal
Of Medicine 330(7): 1129, April 21, 1994.

13. Kohl S, et al: Human colostral cytotoxicity: antibody-dependent cellular
cytotoxicity against herpes simplex infected cells mediated by colostral
cells. Journal of Clinical Laboratory Immunology 1:221-224.

14. Acosta-Altamirano G, et al: Anti-amoebic properties of human colostrum.
Adv Exp Med Biol 216B: 1347-1352, 1987.

15. Boesman-Finkelstein M., et al: Passive oral immunization of children. The
Lancet. 49:1336, 1989.

16. Haynes BF, Fauci AS: Introduction to clinical immunology. Part II,
section 2. in: Harrison’s Principles of Internal Medicine, Eleventh Edition. Braunwald E (eds), et al. New York: McGraw Hill Book Co, Janusz M, et al: Immunoregulatory properties of synthetic peptides:
fragments of a proline-rich polypeptide from bovine colostrum.
Molecular Immunology 24(10): 1029-1031, 1987.

17. Kim K, et al: In vitro and in vivo neutralizing activity of human colostrum and milk against purified toxins A and B of Clostridium difficile. T Infect Dis 150:57-61, 1985.

18. Ogra P, et al: Colostrum derived immunity and maternal neonatal
interaction. Annals NY Acad Sci 409:82-92, 1983.

19. Palmer EL, et al: Antiviral activity of colostrum and serum immuno- globulins A and G. J Med Virol 5:123-129, 1980.

20. Sabirl, AB: Anti-poliomyelitic substance in milk from human beings and certain cows. T Dis Children 80:866-870, 1950.

21. Spik, G., et al., Bacteriostasis of a milk-sensitive strain of E. coli by immuno-
globulins and iron-binding proteins associated with colostrum. Immunology 35:663-670, 1981.

22. Stephan W, et al: Antibodies from colostrum in oral immunotherapy.
J Clin Chem Clin Biochem 28:19-23,1990.

23. Wada N, et al: Neutralizing activity against Clostridium difficile toxins in the
supernatants of cultured colostral cells. Infect Immune 29:545-550,1980.

24. Ferrer-Argote VE; Romero-Cabello R; Hernandez-Mendoza L; Arista-
Viveros A; and others Successful treatment of severe complicated measles with non-specific transfer factor. Department of Hematology, Hospital General de Mexico, DF, Mexico. In Vivo 1994 Jul-Aug; 8 (4): 555-7

25. Rebulla P; Tedesco F; Radillo O; Battaglioli M; and others Inhibition of in vitro adherence of antibody-coated red cells to monocytes by the dialyzable leukocyte extract. Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Policlinico, Milan, Italy. Transfusion 1991 Mar-Apr; 31 (3): 218-21

26. Fazio M; Negri L; Calabrese F; Correggia F; and others A new method for the in vitro transfer of delayed hypersensitivity by dialysed transfer factor. J Nucl Med Allied Sci 1990 Oct-Dec; 34 (4 Suppl): 271-4

27. Fazio M; Calabrese F; Giacomasso S; Meina G; and other Transfer in vivo of tuberculin hypersensitivity by sensitized lymphocytes. Chair of Medical Oncology, University of Turin, Italy. Panminerva Med 1993 Sep; 35(3): 149-53

28. Mrazova A; Mraz J Transfer factor and its signification for practice. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove 1993; 36(3): 117-37

29. Sumiyama K; Kobayashi M; Miyashiro E; Koike M Combination therapy with transfer factor and high dose stronger neo-minophagen C in chronic hepatitis B in children (HBe Ag positive). Department of Pediatrics, Wakayama Medical College, Japan. Acta Paediatr Jpn 1991 Jun; 33(3): 327-34

30. Snirc J; Mikula I; Pistl J The induction of specific protection against Actinobacillus pleuropneumoniae infection by specific DLE. Department of Microbiology and Immunology, University of Veterinary Medicine, Kosice, Slovakia. Acta Microbiol Hung 1993; 40(4): 325-33

31. Qi HY; Wan ZF; Su CZ Isolation and purification of HSV-1 specific transfer factor produced by HSV-1 immunized goat leukocyte dialysate. Department of Biochemistry, Fourth Military Medical University, Xian, P.R. China. Acta Virol 1992 May; 36(3): 231-8

32. Fernandez O; Diaz N; Morales E; Toledo J; and others Effect of transfer factor on myelosuppression and related morbidity induced by chemotherapy in acute leukaemias. Hospital Universitario Dr. Carlos J. Finlay, Marianao, Cuba. Br J Haematol 1993 Jul; 84(3): 423-7

33. Kirkpatrick CH Structural nature and functions of transfer factors. Conrad D. Stephenson Laboratory for Research in Immunology, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.

REVIEW ARTICLE: 26 REFS.
Ann N Y Acad Sci 1993 Jun 23; 685: 362-8


Study Group Profile

Background:

NK cell activity (Lytic Units) in a healthy population 150-225

NK cell activity (Lytic Units) in the U.S. population 20-50

Study Group size and gender:

107 participants:

59 females

48 males

Average age: 53 years

Youngest: 17 years

Oldest : 83 years

Presenting disease as a percentage of the Total Study Group:

Cancer 50%

Chronic Fatigue Syndrome 30%

Others 20%

Including Lupus, Allergies, Fibromyalgia, Blood Disorders, Chronic Infections,

Recurrent Infections, Autoimmune Diseases, and Cervical Dysplasia/Metaplasia.

All Study Group participants recorded significantly higher NK cell activity.

Average initial NK cell activity 18 Lytic Units.

Average final NK cell activity 246 Lytic Units.

Average monthly increase in NK cell

activity by participants 28.25 Lytic Units.

Average percentage of improvement 1,267%.

Treatment period:

Total participant treatment time 1,422 months.

Average participant treatment time 13.2 months.

Number of capsules used by participants:

2-8 per day. 20.


GRAPHIC ILLUSTRATION OF CLINICAL STUDY

  • Average NK Cell activity in a Healthy Population is 150-225

  • Average U.S. Population NK Cell activity is 20-50

  • Study includes over 1400 Treatment months for 107 patients

  • Average monthly increase by patients was 28.25 Lytic Units
  • Participant profile: Average age 53 ( youngest: 17 - oldest: 84)

  • Diseases presented by study participants
    - Cancer
    - Chronic Fatigue Syndrome
    - Lupus
    - AIDS, HIV
    - Hepatitis C
    - Allergies
    - Colitis
    - Chronic Infection

  • Low NK Cell count is associated with a wide spectrum of human illnesses.

Biomune OSF Plus™

The potential benefits available through colostrum and whey are being discussed everywhere. Claims of benefit from the consumption of "Pure, Clean Colostrum" or "Filtered Whey" are everywhere. Indeed, the benefit of breast-feeding infants has covered magazine racks for years.

Bovine colostum is touted as the "new" source of health. Bovine colostrum is now a commodity. Buyers and sellers from all over the world are being brought together for the purpose of creating a new marketable commodity. New companies have emerged to sell this commodity in various forms of "after-market" marketing.

Though bovine colostrum has some demonstrated benefit, by itself bovine colostrum is not a silver bullet. It is simply another commodity like wheat or milk. As with all commodities, all are not created equal and do not contain equal characteristics. Quantum Research, Inc. and Dr. Jesse Stoff have demonstrated that high quality, highly controlled extracts can be combined with other nutritional ingredients to create significant products that can bring changes in the performance of the immune system.

Quantum Research, Inc. is able to create the amazing extracts used in the products for several reasons.

They use a proprietary technology, protected by a totally unique and protected patented process.

They utilize a privately managed dairy herd that originated over thirty years ago.

They access nearly forty years of experience in bovine colostrum collection and study.

Dr. Stoff and/or Dr. Olsztyn have used these extracts for over twenty years in medical practice.

Biomune OSF Plus™ utilizes the herb astragalus in combination with a special extract of dairy colostrum and whey. Clinical studies indicate that this combination creates a synergistic effect on the immune system resulting in elevation of NK cell activity.*


Astragalus
The herb Astragalus, with the Latin name, Astragalus membranaceus, is derived form the root of this perennial herb which is Chinese in origin and considered a traditional Chinese herb. Astragalus is considered an immune stimulation herb. The "stem cells" in the bone marrow are increased and their development is stimulated into active immune cells that are then released into the body. Essentially, every phase of the immune system activity is stimulated by Astragalus.

Active ingredients contained in astragalus include bioflavanoids, choline, and astragalan B, a polysaccharide. Astragalan B has been shown in animal studies to be effective at protecting the body against a number of toxins, controlling bacterial infections and stimulating the immune system. Astragalan B appears to work by allowing the body’s immune system to attack the outer membranes of viruses, destabilizing their defenses and allowing them to be overwhelmed by the immune response.

Astragalus increases interferon production and enhances NK and T cell function, increasing resistance to viral conditions. Astragalus has also been shown to support the body in peripheral vascular disease and peripheral circulation. Astragalus aids adrenal gland function that often needs support in chronic and degenerative health states.

Researchers in China have conducted recent studies which report that Astragalus is an effective treatment for supporting the immune system in cancer patients. Two separate studies followed patients receiving traditional chemotherapy and radiation treatment, which typically devastate the immune system and leave the recipients weak and susceptible to new opportunistic infections. Patients receiving astragalus extracts had twice the survival rate of those only receiving standard therapies. Further studies in the U.S. confirmed that Astragalus has unique immunity enhancement qualities.

Astragalus has been available China for centuries and has a long history of use in traditional medicine in China. It is used to strengthen the Wei Ch’i or "denfensive energy". It is regarded as a tonic for stimulating the immune system and increasing energy levels. It has also been used as a diuretic and a vasodilator for respiratory infections. It has also been used for colds, flu and to increase stamina.

* These statements have not been evaluated by the FDA. This product is not intended to treat, diagnose or cure any diseases.

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Ingredients:

BIOMUNE OSF
Plus


Bovine colostrum/whey extract (Ai/E10®)
Astragalus (root).

Recommended use

BIOMUNE OSF Plus: 1 Capsule a day

® Registered trademark of Quantum research, Inc.